PAI-1 inhibition and aging?

Jay: Some new stuff came across my desk, and I figured I would run it by you. Apparently some Amish people have a mutation in the SERPINE1 gene* that partially inhibits PAI-1 [plasmogen activator inhibitor 1], and this extends their lifespan by, on average, 17 years. Yes, 17 years. They seem to be immune to many diseases of aging - diabetes, heart issues, etc. - and also do not bald or go grey. Interestingly, metformin reduces PAI-1 levels in blood**. Some drugs target PAI-1 directly. Interesting! Are you optimistic about this pathway? *Source 1: https://www.scholars.northwestern.edu/en/publications/a-null-mutation-in-serpine1-protects-against-biological-aging-in- **Source 2: https://diabetesjournals.org/care/article/35/10/1961/38539/PAI-1-and-Diabetes-A-Journey-From-the-Bench-to-the